Synthesis and study of antimicrobial activity of some tetrahydrocarbazole derivatives substituted with NSAID

New tetrahydrocarbazole derivatives substituted at the heteroatom (N) by non-steroidal anti-inflammatory drug (NSAIDs) were synthesized reaction of cyclohehexanon (C.H.N.) with phenyl hydrazine (P.H.Z.) to form (THCZ), where latter is reacted NSAID (Ketoprofen) via amide bond yield
 THCZ, compounds chemical structures verified by: 1H, 13C NMR and FTIR spectroscopy.
 Antifungal activity was investigated docking study in vitro test reveal good antifungal activity, but also showed that have weak moderate antibacterial activity.